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Basic sciences poster session 2: HIV and Hepatitis
P4-S2.02 Regulatory T cells and Fox P3 levels in naive and HAART treated HIV-1 infected patients in Thailand
  1. S Sukwit1,
  2. S Srisurapanon2,
  3. T Chuenchitra1,
  4. N Horthongkham3,
  5. R Sutthent3
  1. 1Armed Forces Research Institute of Medical Sceinces, Bangkok, Thailand
  2. 2Srinakharinwirot University, Thailand
  3. 3Siriraj Hospital, Mahidol University, Bangkok, Thailand


Background The frequency and expression levels of FoxP3 in regulatory T-cells (T-regs) from advanced-stage HIV-infected patients are controversial. Thus, the aims of this study were to compare these parameters of T-regs from HIV infected patients and from healthy controls.

Methods T-reg population and expression levels of FoxP3 were assessed from 43 HIV-1 infected individuals and 12 healthy controls by using FACs flow cytometry.

Results Minor decrease in frequencies of T-regs was found in both infected groups (naïve and treated) compared with those from healthy controls (p=0.02, p=0.01, respectively). In contrast, a significantly increase in the ratios of T-regs: CD4 cells from HIV-infected patients was observed (p=0.001). In addition, FoxP3 expression levels in both treated and untreated HIV-1 infected patients were significantly higher than those in healthy controls (p<0.001 and 0.01 respectively).

Conclusions The decreased number of T-regulatory cells and the increased levels of FoxP3 in T-regs from HIV infected patients were associated with advanced stage of AIDS disease.

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