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Cerebrospinal fluid HIV viral load may be detectable, despite serum viral load being undetectable, in patients diagnosed with syphilis
  1. Eavan Gabrielle Muldoon1,
  2. Suzie Coughlan2,
  3. Fiona Mulcahy1
  1. 1Department of Genitourinary Medicine and Infectious Diseases, St James's Hospital, Dublin, Ireland
  2. 2UCD National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4
  1. Correspondence to Dr Eavan Gabrielle Muldoon, Department of Genitourinary Medicine and Infectious Diseases, St James's Hospital, James's Street, Dublin 8, Ireland; eavan{at}

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With an increasing proportion of male patients co-infected with syphilis and HIV, the management of these patients has become more relevant. HIV and syphilis both enter the central nervous system early in the course of infection, and have been shown to be present at all stages of the disease. Syphilis is reported to increase the serum HIV viral load (VL) in HIV co-infected patients;1 higher CSF HIV VLs …

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  • Funding Funding provided by research bursary awarded by the Infectious Diseases Society of Ireland.

  • Competing interests None.

  • Ethics approval St James's Hospital Research Ethics Committee 2008/05/13.

  • Provenance and peer review Not commissioned; internally peer reviewed.