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Re-evaluation of serological criteria for early syphilis treatment efficacy: progression to neurosyphilis despite therapy—a reply
  1. Francesco Drago,
  2. Aurora Parodi,
  3. Alfredo E Rebora
  1. Department of Health, Section of Dermatology, University of Genoa, Genoa, Italy
  1. Correspondence to Correspondence to Professor Alfredo E Rebora, Department of Health, Section of Dermatology, University of Genoa, 7, Viale Benedetto XV, Genoa 16122, Italy; rebdermo{at}

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We read the article of Zhou and collaborators1 with great interest. We agree that clinicians should be aware that appropriate therapy in early syphilis may be not sufficient for avoiding late-stage disease, neurosyphilis in particular. To support such an important issue, we would like to deliver the data we obtained by a retrospective study we conducted some years ago.

The data were collected in our Section of Dermatology by examining the clinical records of 62 patients diagnosed as having …

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  • Competing interests None.

  • Ethics approval This is retrospective study in which subjects were regular patients with syphilis who have been treated with penicillin many years ago.

  • Provenance and peer review Not commissioned; internally peer reviewed.