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Understanding the interaction between genetic diseases and systemic disorders can stimulate advances in therapeutics, disease pathogenesis and prevention strategies. For example, the rarity of pulmonary tuberculosis in patients with cystic fibrosis,1 protection against Epstein Barr viral infection in X linked agamaglobulinemia2 and amelioration of common variable immune deficiency by acquisition of HIV3 contributed significantly to the understanding of genetic and mechanistic pathogenesis of tuberculosis and HIV.
In this edition of STI, Nouraie and colleagues4 analysed hospital discharge data …
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.