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Letter
PCR detection in diagnosis of early syphilis: a preliminary result from China
  1. Rui-Rui Peng1,2,
  2. Yue-Ping Yin1,3,
  3. Wan-Hui Wei1,3,
  4. Hong-Chun Wang1,3,
  5. Jin-Ping Zhang1,
  6. Xiang-Sheng Chen1,3
  1. 1Institute of Dermatology of Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China
  2. 2Shanghai Skin Disease Hospital, Shanghai, China
  3. 3National Center for STD Control, Nanjing, China
  1. Correspondence to Dr Xiang-Sheng Chen, National Center for STD Control, 12 Jiangwangmiao Street, Nanjing 210042, China; chenxs{at}ncstdlc.org

https://doi.org/10.1136/sextrans-2012-050894

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    Recently, Gayet-Ageron and colleagues published a systematic review and meta-analysis to evaluate the diagnostic values of Treponema pallidum PCR and concluded that PCR is a useful additional diagnostic tool.1 However, the data on examining diagnostic performance of PCR-based methods for early syphilis are still limited in China although a few studies with the indirect data from China were included in the literature review.1

    During April to September 2009, we conducted a survey among patients with suspected primary or secondary syphilis recruited from an STI clinic in Nanjing, China, to evaluate the performance of PCR assay for early syphilis diagnosis. Following an ethical review by …

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    Footnotes

    • Contributors XSC was the principal investigator of the study. RRP, YPY and XSC designed the research frame. RRP, WHW, HCW and JPZ were responsible for the study implementation and the laboratory detections. RRP and XSC were responsible for data analyses and manuscript preparation. All authors commented on the manuscript and concurred with the final submission.

    • Funding This work was supported by the National Institute of Allergy and Infectious Diseases, Sexually Transmitted Infections and Topical Microbicide Cooperative Research Center (5U19 AI031496-18).

    • Competing interests None.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; internally peer reviewed.