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The systematic review and meta-analysis by Lissouba and colleagues adds to mounting data showing a strong association between genital human papillomavirus (HPV) infection and the risk of HIV acquisition, with an estimated summary odds ratio of 2.0 (95% confidence interval 1.6 to 2.5) for HIV acquisition associated with any-HPV infection. The strongest reported estimates are specific to clearance of HPV infection, suggesting that the association between HPV and HIV acquisition may not be fully attributable to confounding by other sexually transmitted infections (STIs) or co-transmission.1 ,2 …
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