Background HPVgenital infections is not yet a STD to be reported. The actual incidence and prevalence are increasing and should be updated using new molecular biology techniques. In men it is more difficult to establish prevalence because of difficult sampling of a suitable biological product.

Methods The study involved the participation of 105 men (2006–2011), aged 18–55 years, selected from patients with external anogenital lesions with HPV suspected aetiology or who had partner/sexual partners with clinical lesions and/or positive test for HPV. The tests used for HPV DNA detection and genotyping were: HPV INNO - Lipa HPV genotyping Line Probe Assay EC (Innogenetics) and LINEAR ARRAY HPV genotyping test (Roche Diagnostics).

Results HPV distribution and the genotypes most commonly found were: in men without clinical signs - 26 cases (24.76%)/HPV 18, 45, 6, 11, 16, 31, 33, 61, 66, CP6108, and those with acuminate and external genital flat warts –16 cases (15.23%)/HPV 6, 11, X (indeterminate), 40, 45, 55 - single or multiple infection.

The applied treatment was: Inosinum PO for porting cases, Inosinum PO and CO₂ laser vaporisation for those with external anogenital warts acuminata 13 cases (12.38%), or Inosinum PO and local podophyllotoxin 0.5% for those with external genital warts flat 3 cases (2.85%).

Conclusion Proper counselling of symptomatic or asymptomatic male patients infected with HPV, together with using all investigative protocols and personalised therapy, provides, in 90% of cases, healing of external genital lesions induced by HPV virus and negative results for HPV tests.