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P3.265 Discordant Couples in HIV/AIDS Cycle
  1. R N Mbugua
  1. Kenya Medical Researach Institute, Nairobi, Kenya


Objectives A large proportion of new HIV infections in sub-Saharan Africa occur in stable HIV-discordant partnerships. In some couples, the strong desire to conceive a child may lead to risky behaviour despite knowledge of discordant serostatus. Our objective was to compare HIV transmission between discordant couples who did and did not conceive during participation in a clinical trial. Methods: Five hundred and thirty-two HIV-discordant couples were followed for up to 2 years in Kenya Network of Women Living with HIV/AIDS Kenya as part of the Partners in Prevention HSV/HIV Transmission Study. Quarterly HIV-1 antibody and urine pregnancy test results were analysed. Results: Forty-one HIV-1 seroconversions occurred over 888 person-years of follow-up, resulting in an annual incidence of 4.6/100 person-years. Twenty seroconversions occurred among 186 HIV-1-uninfected individuals in partnerships in which pregnancy occurred (10.8% of HIV-1-negative partners in this group seroconverted), in comparison to 21 seroconversions among 353 uninfected individuals in partnerships in which pregnancy did not occur (5.9% of HIV-1-negative partners seroconverted), resulting in a relative risk of 1.8 [95% confidence interval (CI) 1.01–3.26.

Conclusions Pregnancy was associated with an increased risk of HIV sero conversion in discordant couples. These data suggest that the intention to conceive among HIV discordant couples may be contributing to the epidemic. There are an estimated 33 million people in the world infected with HIV, 60% of whom reside in sub-Saharan Africa. Emerging data indicate that a large proportion of new infections in this region occur in stable HIV discordant relationships. Prevention efforts in this population have focused on couples-based HIV testing to equip partners with knowledge of their serostatus in order to motivate behaviour change.

  • discordant serostatus
  • HIV transmission
  • HIV-discordant partnerships

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