A qualitative exploratory-descriptive objective “Identify the elements that influence the perception of quality of life (QOL) of people living with HIV/AIDS”. Semi-structured interviews with 14 people have been carried out. The analysis resulted in four categories Quality of life: subjectivity and multidimensionality. Living with HIV/AIDS and the quality of life. Care for the living quality. Health services as enhancers of QOL. There are several factors that interfere on the QOL of those people such as: physical aspects caused by the disease, the continuation of the treatment and the usage of antiretroviral medications. As social aspects, we have identified the presence of prejudice and discrimination. The acceptance of the treatment by antiretroviral medications considerably improves QOL. The identification of the factors that interfere on QOL will be able to contribute to the more humanised service provided to people who live with HIV/Aids, leading the care beyond the clinical aspects, instrumentalizing those people towards a living with more life quality.