Introduction The Human immunodeficiency virus (HIV) infection remains a serious health problem globally. Recently, the Prevention of mother-to-child transmission (PMTCT) programmes have gained meaningful achievements, although not evenly spread especially in resource-constrained settings. This study objective is to determine the prevalence of pregnancy with HIV concerning the characteristics of maternal and perinatal outcomes in Prof. Dr. R. D. Kandou Central Hospital as the national referral hospitals in north-eastern part of Indonesia.

Methods This is a cross sectional study with data collected from medical records at the VCT clinic at Prof. Dr. R. D. Kandou Central Hospital Manado after the implementaton of PMTCT program which is from January 2011–December 2014.

Results During the period there are 17 cases of mother with HIV infection. Patients who consume drugs regularly during pregnancy as much as 93.33%, with an overall undetectable HIV infants. About 70% were delivered by sectio caesarean method. The rest of 6.67% were not taking ARVs regularly and resulted with CD4 <200/mm³ and HIV-infected infants.

Conclusion During the program, numbers of HIV in pregnancy cases were discovered and more MTCT cases were prevented. However a more comprehensive and active strategic approach for the PMTCT programmes need to be taken to prevent HIV infection in infants.

Disclosure of interest statement No grants were received in the development of this study.