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O19.3 Pills, pleasure and privacy: early experiences of pre-exposure prophylaxis among men in the vicprep study
  1. DA Murphy1,2,
  2. JBF de Wit1,
  3. L Lal3,4,
  4. JM Audsley4,5,
  5. N Roth6,
  6. R Moore7,
  7. BK Tee8,
  8. T Read9,
  9. E Wright3,4,10
  10. on behalf of the VicPrEP Study Team
  1. 1Centre for Social Research in Health, UNSW
  2. 2National Drug Research Institute, Curtin University
  3. 3Department of Infectious Diseases, The Alfred Hospital
  4. 4Burnet Institute
  5. 5Doherty Institute for Infection and Immunity
  6. 6Prahran Market Clinic
  7. 7Northside Clinic
  8. 8Centre Clinic
  9. 9Melbourne Sexual Health Centre
  10. 10Department of Infectious Diseases, Monash University


Background There has been limited research on the lived experience of taking antiretrovirals as HIV pre-exposure prophylaxis (PrEP). We explored men’s experiences as participants in Australia’s first PrEP demonstration project.

Methods After attending clinic visits, participants completed a self-report online survey on behaviour, attitudes and experiences. This paper analyses responses to the first (i.e. 3-month) survey on: 1) pill taking (including adherence and interruptions); 2) sex since starting PrEP; and 3) disclosing PrEP use. Responses to items on experiences of PrEP were measured on a 5-point scale (1 = strongly disagree, 5 = strongly agree).

Results At 31 March 2015, 76 participants had completed a 3-month survey; all gay/bisexual men (mean age 37.7 years). Forty-one men (53.9%) reported missing any PrEP doses. The median number of doses missed was 1 (mean 2.04). Missing doses was most commonly attributed to forgetting. Six men reported interrupting PrEP for 2 days or more. Side-effects (usually mild) were reported by 34 men (44.7%).

Participants strongly agreed that PrEP had reduced their worries about HIV acquisition (mean 4.53; SD 0.77); they agreed that they were open with sexual partners about PrEP (mean 4.20; SD 1.2), and agreed that PrEP made them feel more confident about sex (mean 4.17; SD 0.98). Participants moderately agreed that they were careful to whom they disclosed (mean 3.36; SD = 1.4). However they disagreed that they had experienced negative reactions (mean 1.99; SD 1.14), and disagreed that potential sex partners would avoid them (mean 2.03; SD 1.01)

Conclusion These findings are notable because they support the results of recent qualitative research on the role of PrEP in decreasing anxiety around HIV. Caution around disclosure (including to sexual partners) suggests concern about negative reactions (despite few actual occurrences) and underscores the current novelty of PrEP as a prevention strategy.

Disclosure of interest statement The VicPrEP study was funded by the Victorian Department of Health and study drug was supplied by Gilead. Dean Murphy receives funding from the Australian Government Department of Health and a research grant from the Victorian Department of Health.

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