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Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation
  1. Praveen Kumar1,
  2. Darshan Singh Bhakuni2,
  3. Geetika Khanna3,
  4. Sumit Batra3,
  5. Vinod Kumar Sharma3,
  6. Sangita Rastogi1
  1. 1Microbiology Laboratory, National Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India
  2. 2Department of Rheumatology and Clinical Immunology, Army Hospital (Research & Referral), New Delhi, India
  3. 3Central Institute of Orthopaedics, Vardhaman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
  1. Correspondence to Dr Sangita Rastogi, Microbiology Laboratory, National Institute of Pathology (ICMR), Post Box No. 4909, Safdarjung Hospital Campus, New Delhi 110029, India; rastogi_sangita{at}

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Chlamydia trachomatis (C. trachomatis)-induced reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) are unrecognised/underestimated entities, and clinicians often fail to recognise them. In India, our group was the first to report intra-articular C. trachomatis infection in patients with ReA/uSpA having genitourinary symptoms.1 Males were predominant (78%) and majority of patients presented with an oligoarthritic profile (80%), enthesitis (11%) and human leukocyte antigen (HLA) B27 (40%); however, none reported ocular infection. Despite this observation, it is also very likely that C. trachomatis-induced ReA/uSpA is underdiagnosed in women.

Intra-articular C. trachomatis …

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  • Contributors PK performed immunoassays, interpretation of data, statistical analysis and prepared draft of the manuscript. DSB collated data and contributed to the journal letter. GK and SB were responsible for collection of patient data and clinical samples, while VKS assisted in patient enrolment. SR conceived the concept of the study, interpreted the data and critically revised the manuscript. All authors read and approved the final manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study had the approval of Vardhman Mahavir Medical College (VMMC) & Safdarjung Hospital Ethics Committee (No. 6–10 EC-6/9).

  • Provenance and peer review Not commissioned; internally peer reviewed.