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Case report
Macrolide and quinolone-resistant Mycoplasma genitalium in a man with persistent urethritis: the tip of the British iceberg?
  1. Suneeta Soni,
  2. Andy Parkhouse,
  3. Gillian Dean
  1. Sexual Health and Contraception, Brighton and Hove, UK
  1. Correspondence to Dr Suneeta Soni, Lawson Unit, Royal Sussex County Hospital, Eastern Rd, Brighton BN2 5BE, UK; Suneeta.soni{at}


There is growing concern worldwide for macrolide resistance in M. genitalium following liberal use of 1 g azithromycin to treat non-gonococcal urethritis and confirmed C. trachomatis infection. Moxifloxacin is the second-line treatment for M. genitalium and still has excellent efficacy against it. However, recent reports indicating that quinolone resistance is more prevalent than previously thought are worrying. Routine testing of symptomatic men and women for M. genitalium is not currently recommended in BASHH guidelines, and attempts to implement such testing have been hampered by a lack of commercially available assays. We present a case of M. genitalium urethritis which failed to respond to four different antibiotic regimens, resulting in multiple visits to the clinic and anxiety for the patient.

  • NGU

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  • Contributors SS, AP and GD all saw the patient in clinic. SS wrote the first and final draft of the manuscript. AP and GD commented on the first and final draft of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.