Introduction Gonococcal infections have been a major sexually transmitted disease (STD) since 1980s’and also a serious public health problem in China. A national surveillance report showed that the number of reported gonorrhoea cases were 1 00 245 in 2015. Resistant gonococcal infections are the obstacle in control work of the disease, which not only affect the treatment as well as the development of complications, but also facilitate the further transmission. The WHO has been drafted a global action plan to control the spread and impact of antimicrobial resistance in Neisseria Gonorrhoeae. This report will to analysis the susceptibility trends of NG to ciprofloxacin, spectinomycin, and ceftriaxone from 2005 to 2013 in China including PPNG and TRNG rate.

Methods The production of β-lactamase was determined by paper acidometric testing method. Antimicrobial susceptibility testing was performed for tetracycline, ciprofloxacin, spectinomycin, and ceftriaxone using the agar dilution method. Establishment of quality control standards and system, which provide regular examination of participant laboratories through sending quality control strains, as well as through field supervision in China.

Results About 11625 NG isolates were collected from patients with uncomplicated gonorrhoea in 2005–2013. A total of 4565 (39.27%) PPNG were and 4807 (41.21%) TRNG were identified, with an increase from 28.09% in 2005 to 39.15% in 2013. A total of 11 178 (96.16%) ciprofloxacin-resistant strains were identified and the rate of ciprofloxacin-resistant strains keep stable from 2005 to 2013. All of isolates were susceptible to spectinomycin and ceftriaxone from 2005–2013, but a total of 4325 (36.79) ceftriaxone-intermediate strains were identified.

Conclusion Antimicrobial susceptibility of NG isolated in China from 2005 to 2013 was characterised by high rate of PPNG, TRNG, and ciprofloxacin -resistant strains. Results of the study illustrate that spectinomycin and ceftriaxone can be considered as the choice drugs for empirical treatment of infection in China.