Introduction In the context of the National Strategic Plan for HIV-AIDS, STIs 2013–2017 and the responsibility assumed in the Strategy for Elimination of Mother-to-Child Transmission of HIV, Syphilis, the National Program compile the results of qualitative investigations were carried out by different professionals working in the public system to evaluate the possibility of defining and implementing effective and creative strategies to get better diagnosis and treatment to reduce prenatal HIV transmission.Generate new strategies of action and intervention to reduce the gap in the prenatal transmission of HIV and Congenital Syphilis in Argentina.

Methods We collected the results of four qualitative investigations: ”HIV-AIDS: vertical transmission. Incidence of social and health factors ” Representations around the vertical transmission of HIV/AIDS: the construction of meaning from the perspective of professionals and mothers of children with HIV/AIDS “ ”Women living with HIV/AIDS, maternity and mental health: social support, psychic suffering and relationship with health services” and “Qualitative study on the perspective of mothers residing in the provinces with the highest HIV prevalence in Argentina”. The main conclusions of each study were analysed to interpret how to generate new lines of political organisation in health to reduce the prenatal transmission rate of 5% to 2%.

Results The possible strategies proposed were: Include safety support from social workers, include of mental health practices as part of the comprehensive care of pregnant women with HIV, Decentralise the hospital level for follow-up and treatment in the prevention of prenatal HIV transmission, Active offer HIV testing of the pregnant woman’s partner - Involve civil society as promoters in the prevention and companions of families with HIV to improve access to the health system and promise a cooperative action work with the health system.

Conclusion The prenatal HIV elimination strategy is a complex network between different social actors and an efficient health system.