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Original article
Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: a case–control study
  1. Robin van Houdt1,2,
  2. Bing Ma3,
  3. Sylvia M Bruisten2,
  4. Arjen G C L Speksnijder4,
  5. Jacques Ravel3,
  6. Henry J C de Vries2,5
  1. 1 Department of Medical Microbiology and Infection Control, VU Medical Center, Amsterdam, The Netherlands
  2. 2 Department of Infectious Diseases, Public Health Service, Amsterdam, The Netherlands
  3. 3 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA
  4. 4 Naturalis Biodiversity Center, Leiden, The Netherlands
  5. 5 Department of Dermatology, Academic Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Dr Robin van Houdt, Department of Medical Microbiology and Infection Control, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands; r.vanhoudt{at}vumc.nl

Footnotes

  • Handling editor Jackie A Cassell

  • Contributors RvH, AGCLS and HJCdV conceived and designed the study and obtained funding. RvH and SMB performed laboratory analyses of the samples. RvH, AGCLS and HJCdV participated in data collection. RvH and BM performed data management, and genomic and statistical analyses. RvH wrote the manuscript. JR facilitated and contributed to the genomic analyses. All authors contributed to data interpretation, reviewed successive drafts and approved the final version of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Ethics Committee of the Free University of Amsterdam.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Handling editor Jackie A Cassell

  • Contributors RvH, AGCLS and HJCdV conceived and designed the study and obtained funding. RvH and SMB performed laboratory analyses of the samples. RvH, AGCLS and HJCdV participated in data collection. RvH and BM performed data management, and genomic and statistical analyses. RvH wrote the manuscript. JR facilitated and contributed to the genomic analyses. All authors contributed to data interpretation, reviewed successive drafts and approved the final version of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Ethics Committee of the Free University of Amsterdam.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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