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Nine-valent human papillomavirus (HPV) vaccination could potentially prevent 90% of cervical cancer
Quadrivalent (qHPV) and bivalent vaccines against HPV are now used widely. The nine-valent HPV (9vHPV) vaccine protects against HPV 6, 11, 16, 18 already contained in the qHPV but additionally five more types associated with cervical cancer: 31, 33, 45, 52 and 58.
This randomised controlled double-blind, efficacy and safety study1 of the 9vHPV vaccine was carried out in 18 countries. Inclusion criteria were: healthy women aged 16–26, no history of abnormal cervical cytology or biopsy and maximum of four lifetime sexual partners. 14 215 participants received three injections of 9vHPV vaccine or qHPV control at day 1 and months 2 and 6. Cervical cytology, labial, vulvar, perineal, perianal, endocervical and ectocervical swabs were taken and genital examinations were performed on day 1, months 7, 12 and every 6 months after up to month 54. Swabs were tested for nine HPV types above. Serum was taken on day 1 and at intervals to 60 months to assess serological response.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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