Background In 2016, Nigeria recorded 37,000 new HIV infections among children out of the total of 60,000 new infections in West and Central Africa, representing 62 per cent of the new infections. This study was conducted to determine the outcomes of HIV exposed infants and the risk of acquiring HIV infections at the final outcome of 18 months

Methods This is a retrospective cohort study of exposed infants between January 2015-december 2016.A proforma was used to abstract information from clinic records on socio-demographics characteristics, ARV prophylaxis, mode of delivery, birth weight, infant prophylaxis, Early infant diagnosis (EID), referral to ART. Cox proportion hazard regression model was used to determine the risk of acquiring HIV infection at 18 months among the exposed infants.

Results A total of 170 exposed infant were recruited and more than two-third of the infants were males (74.1%) with median age was 4±3 months.One hundred and fifty (88.2%) received infant prophylaxis and 116 (68.2%) had EID done at 6weeks. Of the 170 exposed infants 19(11.1%) were positive at 18 months final outcome of which 4(21.1%) died. Time from being confirmed HIV positive to starting ART was 4.0±2.1 months. COX regression showed that the risk of acquiring HIV infection in females (Adjusted HR = 0.56,95% CI 0.37–0.87), babies who received infant prophylaxis (Adjusted HR= 0.5,95%CI 0.1 -0.9), infants whose maternal CD4 count < 500(Adjusted HR= 1.1,95%CI 0.4 -2.6) and time of starting ART> 3 months (Adjusted HR= 3.5,95%CI 1.8–11.5).

Conclusion The positivity rate among studied exposed infants was high. Continuous placement of HIV positive mothers and exposed infants on prophylaxis, timely initiation of ART will go a long way in reducing the burden of pediatric HIV.

Disclosure No significant relationships.