Background Human immunodeficiency viral (HIV) induce production of autoantibodies could attack the person’s immune system. Patients with HIV infection might present with more severe complications of psoriasis, a chronic autoimmune inflammatory skin disease. But there were insufficient evidences prove the risk between HIV and psoriasis.

Objectives Systematic review was performed to explore the association between HIV and psoriasis, to provide risk assessment and improve patient outcomes.

Methods We used the search strategy: ‘(psoriasis OR psoriatic arthritis) AND (AIDS OR HIV OR acquired immune deficiency syndrome OR human immunodeficiency virus OR CD4 OR CCR5-delta32)’ in searching the Cochrane Library, PubMed and EMBASE electronic databases without language restrictions in May 2018.

Results Four cohort study (187954 participants) were included in this review. Studies report the results of the incidences of psoriasis with patients with HIV infection. While the total incidence on current data of psoriasis was 0.46%, HIV patients had higher risk than normal for developing newly diagnosed with psoriasis whether receiving substance treatment or not. However, psoriasis patients in general do not appear to have increased infection rates of HIV.

Conclusion The available evidence shows that HIV is a potential risk factor for psoriasis. The evidence at the present stage only supports the relationship between HIV infection and psoriasis, but more literature is needed to support such relevance.

Disclosure No significant relationships.