Background Sub-Saharan Africa faces and is severely affected by many conflicts. Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) threaten both the physical and financial well-being of individuals in struggling countries. Research indicates that negative attitude towards HIV/AIDS as well as persons infected with the virus persist despite the increased knowledge of prevention. This research aims to explore and describe the immigrants’ attitudes and beliefs regarding HIV and AIDS in the Mopani district, Limpopo Province.

Methods A quantitative descriptive design was used. The target population was all immigrants at Mopani district in Limpopo province and the sample comprised of males and females. Data was collected using a questionnaire with closed and open-ended questions. Ethical standards were maintained.

Results The study revealed that many participants expressed discriminatory practice towards individuals infected by HIV and those with AIDS. Many viewed promiscuity and the disease called Makhume (meaning illness caused by the omission of purification rites following the death of a family member) as the cause for HIV and AIDS.

Conclusion The findings may hinder the achievement of healthy lives and promotion of well-being at all ages if not addressed appropriately. The collaboration of various departments (Health, Social development, Education, and etc.) in the Mopani district is required to change these negative attitudes and beliefs that influence immigrants’ behaviour. In addition, the use of audio-visuals and peer teaching may help to change their attitudes since they have shown to be most successful in changing the attitudes.

Disclosure No significant relationships.