Background Anogenital wart is one of the most common sexual transmitted infection with varying number of cure rate. Currently self applied therapy is not widely available in Indonesia, except 5-Fluorouracil (5-FU) which could be obtained from 5-FU solution and had been tested for the drug stability. Standard topical therapy in Indonesia is 90% trichloroacetic acid solution (TCA), need 4–6 times until lesion improved. Since TCA requires weekly visit, so it could decrease the treatment compliance. Therefore the self applied therapy may become more favourable. We aim to know the effectivity and safety of 1% 5-FU and 5% 5-FU cream compared to 90% TCA solution in the treatment of anogenital wart.

Methods A randomised control study with intention to treat analysis conducted on January-Mei 2018 in 72 subjects. Allocated to three group 1% 5-FU, 90% TCA, and 5% 5-FU. Response of therapy and side effect (subjective and objective) were evaluated each week, up to seven weeks.

Results Evaluation at week 7 demonstrated that there was no significant difference on the effectivity between 1% 5-FU and 90% TCA (p=0,763), as well as on the effectivity between 5% 5-FU and 90% TCA (p=0,274). Subjective side effect in 1% 5-FU was significantly milder than 90% TCA (p=0,004), but the significant milder objective side effect only found at week 2,6, and 7 (p<0,05). Meanwhile subjective side effect in 5% 5-FU was also significantly milder than 90% TCA (p=0,001), but the significant milder objective side effect only found at week 2 (p=0,000).

Conclusion 1% 5-FU and 5% 5-FU cream have no difference effectivity compared to 90% TCA. Regarding the side effect, 1% 5-FU has significantly milder than 90% TCA. We concluded that 5-FU may become alternative topical therapy with self-application as the benefit and 1% 5-FU cream is more recommended due to milder side effect.

Disclosure No significant relationships.