Article Text

Download PDFPDF

P386 Cancer risk among people with HIV, HBV and/or HCV infections
Free
  1. Maryam Darvishian1,
  2. Carmine Rossi2,
  3. Stanley Wong3,
  4. Amanda Yu3,
  5. Jason Wong3,
  6. Jane Buxton1,
  7. Mark Gilbert3,
  8. Mawuena Binka3,
  9. Zahid Butt1,
  10. Sofia Bartlett1,
  11. Margo Pearce1,
  12. Maria Alvarez3,
  13. Darrel Cook3,
  14. Troy Grennan3,
  15. Ryan Woods4,
  16. John Spinelli4,
  17. Mark Tyndall1,
  18. Mel Krajden5,
  19. Naveed Janjua3
  1. 1University of British Columbia, Vancouver, Canada
  2. 2BC Centre for Disease Control, Clinical Prevention Services, Vancouver, Canada
  3. 3British Columbia Centre for Disease Control, Vancouver, Canada
  4. 4BC Cancer, Vancouver, Canada
  5. 5BC Centre for Disease Control, Vancouver, Canada

Abstract

Background HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections each are associated with increased cancer risk. In this study, we assessed the effect of co-occurrence of HIV, HBV and HCV on all cancers, anal cancer, non-Hodgkin Lymphoma (NHL) and liver cancer.

Methods We used the British Columbia Hepatitis Testers Cohort (BC-HTC) which includes all individuals (∼1.7 million) tested for HCV or HIV, or diagnosed with HCV, HIV, or HBV linked with data on cancers. We included individuals tested for all three infections since 1990 and followed them from the date of their last test until the first cancer diagnosis, death, or 12/31/2015. We utilized the Fine and Grey competing risks regression model to estimate adjusted sub-distributional hazard ratios (aHRs) for outcomes, with death as a competing risk.

Results Among 514,501 individuals tested for all infections, 12,586 had any cancer (2.45%), 100 had anal cancer (0.02%), 552 had NHL (0.11%), and 1,081 had liver cancer (0.21%) during a median follow-up of 4.19 years. Compared to no infection, the aHR for all cancers was the highest for HIV/HBV co-infections (HR 2.55, 95% CI: 1.91–3.42) followed by triple infections (aHR 2.29, 95% CI: 1.80–2.89). The risk of anal cancer was higher among individuals with HIV (triple infection aHR 22.61, 95% CI: 7.27–70.33), while risk of the liver cancer was higher among those with HBV or HCV mono or co-infections and triple infections. The risk of NHL was the highest among HIV/HBV co-infections followed by triple infection.

Conclusion HIV, HBV and HCV infections are associated with an overall higher risk of cancer. The highest risks for anal cancer and NHL were among those living with HIV infection. The observed association between HCV and anal cancer, which may be due to the presence of human papillomavirus and/or residual confounding, requires further investigation.

Disclosure No significant relationships.

  • co-infection
  • viral hepatitis
  • viral STIs
  • HIV

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.