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Poster Presentations
PS02 – POSTER VIEWING SESSION – TUESDAY
Tuesday, July 16, 2019 5:45 PM – 7:00 PM
P520 HPV infections and flat penile lesions of the penis in men who have sex with men
Free
  1. Ward Van Bilsen1,
  2. Alexandra Kovaleva1,
  3. Maaike Bleeker2,
  4. Audrey King3,
  5. Sylvia Bruisten1,
  6. Wilma Brokking4,
  7. Henry De Vries5,
  8. Chris Meijer2,
  9. Maarten Schim Van Der Loeff1
  1. 1Public Health Service of Amsterdam, Department of Infectious Diseases, Amsterdam, Netherlands
  2. 2Amsterdam UMC, Vrije Universiteit-University Medical Center, Department of Pathology, Amsterdam, Netherlands
  3. 3Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
  4. 4DC Klinieken, Department of Internal Medicine, Amsterdam, Netherlands
  5. 5Public Health Service Amsterdam, Amsterdam University Medical Center (UMC), National Institute of Public Health and the Environment (RIVM), Infectious Diseases, Infection and Immunity Institute (AI and II), Epidemiology and Surveillance Unit, Amsterdam, Netherlands

Abstract

Background Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM).

Methods In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous study. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. If tested positive for HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and/or 59, we determined the HPV viral load (VL), using type-specific L1-targeting quantitative (q)PCR. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL.

Results We included 116 MSM, of whom 59/116 (51%) were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and in 34/62 (55%) MSM without FPL (p=0.8). Among MSM with FPL, 16/54 (30%) had an hrHPV infection and 23/54 (43%) had a lrHPV infection, which did not significantly differ from MSM without FPL (p=0.5 and p=0.4, respectively). A detectable HPV VL was found in 10/54 (19%) MSM with FPL and in 10/62 (16%) MSM without FPL (p=0.6). Among MSM with FPL, 27/54 (50%) were HIV-positive and 5/54 (9%) were circumcised, and among MSM without FPL, 32/62 (54%) were HIV-positive and 13/62 (21%) were circumcised (p=0.9 and p=0.09, respectively).

Conclusion Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status, which is in contrast with findings among heterosexual males. Our findings imply that FPL are not useful in identifying HPV infections with a high transmission potential in this population.

Disclosure No significant relationships.

  • gay bisexual and other men who have sex with men
  • HPV

https://doi.org/10.1136/sextrans-2019-sti.598

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