Trans communities across the world are disproportionately burdened by HIV and STIs. Structural, institutional, social, and individual factors have been implicated as drivers of HIV/STI vulnerability. This plenary presentation will summarize the global epidemiology of HIV/STIs and their multi-level drivers among trans populations. Relationships between stigma, sex work, and co-occurring syndemics of substance use, violence, HIV/STIs will be described. Data on effective behavioral and biomedical interventions to prevent HIV/STI acquisition among transgender adolescents and adult will be reviewed. The impact of gender-affirming medical interventions on HIV/STI acquisition risk will be discussed as well as the latest data on pre-exposure prophylaxis uptake, adherence, and drug-drug interactions. More research is needed on HIV/STI epidemiology among trans masculine and gender non-binary individuals, and gaps remain in basic data from trans communities in sub-Saharan Africa and Eastern Europe/Central Asia. Where epidemiologic data exist, implementation science studies are needed to inform how best to implement and scale up multi-component, high impact, prevention care and treatment interventions that address multilevel barriers to HIV/STI prevention and treatment.

Disclosure No significant relationships.