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P747 Characteristics of chlamydia/gonorrhea infections associated with a subsequent syphilis diagnosis in british columbia, canada
  1. Theodora Consolacion1,
  2. Janyn Mercado1,
  3. Olga Mazo1,
  4. Venessa Ryan1,
  5. Linda Hoang2,
  6. Muhammad Morshed2,
  7. Mark Gilbert1,
  8. Mark Hull3,
  9. Troy Grennan1,
  10. Jason Wong1
  1. 1British Columbia Centre for Disease Control, Vancouver, Canada
  2. 2British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada
  3. 3British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada


Background Since 2010, infectious syphilis rates have risen dramatically in British Columbia (BC), Canada. We examined whether characteristics of a chlamydia (CT) or gonorrhea (GC) diagnosis were associated with a subsequent infectious syphilis diagnosis.

Methods All CT and GC diagnoses in BC from 2006 to 2017 were linked to infectious syphilis diagnoses in the subsequent 12-month period. A multivariable logistic regression model was used to identify factors associated with a subsequent infectious syphilis diagnosis and adjusted odds ratios (aOR) with 95% confidence intervals (CI) were reported.

Results Of the 133,264 CT/GC diagnoses, 819 (0.6%) linked to a subsequent syphilis diagnosis. Most were male (777/819, 94.9%) with a mean age of 36.1 years (standard deviation=11.2 years) and had ≥3 CT/GC diagnoses (419/819, 51.2%). At time of CT/GC diagnosis, 222 (27.1%) were living with HIV which increased to 245 (30.0%) at the time of a syphilis diagnosis. The odds of a subsequent syphilis diagnosis were greater among men (aOR=12.2, 95%CI: 8.4–17.7); older age groups of 25–29 years (aOR=1.5, 95%CI: 1.1–2.1), 30–39 years (aOR=2.4, 95%CI: 1.8–3.2), 40–59 years (aOR=3.7, 95%CI: 2.8–4.9), and ≥60 years (aOR=2.6, 95%CI: 1.3–5.0) when compared to age group 20–24 years; those living with HIV at time of CT/GC diagnosis (aOR=9.9, 95%CI: 7.6–12.9); those with a history of lymphogranuloma venereum (aOR=3.4, 95%CI: 2.3–5.2); those with a CT/GC diagnosis from 2012 onward (aOR=4.7, 95%CI: 3.7–5.9); and those with a history of 3 or 4 CT/GC diagnoses (aOR=13.2, 95%CI: 10.6–16.3) or 5+ CT/GC diagnoses (aOR=44.6, 95%CI: 34.8–57.1) when compared to those with 1 or 2 diagnoses.

Conclusion Characteristics of CT/GC diagnoses that were associated with a subsequent infectious syphilis diagnosis included male gender, older than age 24 years, co-infected with HIV, history of lymphogranuloma venereum, diagnosis of CT/GC from 2012 onward, and a history of 3+ CT/GC diagnoses.

Disclosure No significant relationships.

  • syphilis
  • Neisseria gonorrhoeae
  • risk factors
  • chlamydia

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