You are here

Article Text

Article menu

Download PDFPDF

Poster Presentations
PS02 – POSTER VIEWING SESSION – TUESDAY
Tuesday, July 16, 2019 5:45 PM – 7:00 PM
P826 High prevalence of cervical HR-HPV in immigrant women originating from sub-saharan africa and living in orléans, france
Free
  1. Ralph Sydney Mboumba Bouassa1,
  2. Camelia Gubavu2,
  3. Mathieu Matta3,
  4. Leman Robin3,
  5. David Veyer3,
  6. Anne Gravier2,
  7. Laurent Hocqueloux2,
  8. Thierry Prazuck2,
  9. Hélène Péré3,
  10. Laurent Bélec3
  1. 1Ecole Doctorale d’Infectiologie Tropicale, Tropicale Infectiologie, Franceville, Gabon
  2. 2Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Régional d’Orléans, Orléans, France
  3. 3Laboratoire de Virologie, Hôpital Européen Georges Pompidou and Faculté de Médecine Paris Descartes, Université Paris Descartes (Paris V), Sorbonne Paris Cité, Paris, France

Abstract

Background We herein assess the HPV detection and HPV-related cervical lesions in immigrant African women living in France.

Methods In 2018, immigrant African adult women attending for sexual health and HIV care a French healthcare facility, were included and subjected to endocervical swabs and Pap smear. HPV DNA was detected by multiplex real-time PCR (AnyplexTM II HPV28, Seegene, Seoul, South Korea).

Results 50 African immigrant women (mean age, 41.7) residing in France for an average of 10.7 years (range 1–32), including 74.0% of HIV-positive and 26.0% of HIV-negative, were prospectively included. HPV prevalence was 68.0%, with 56.0% of HR-HPV and 24.0% of multiple HPV. Unexpectedly, the non-vaccine HR-HPV-68 (20.0%) was the predominant genotype, followed by the Gardasil-9® vaccine HR-HPV-58 (14.0%). HPV-16 and HPV-18 were respectively detected in 6.0% and 10.0%. HIV-infected women were more infected with HR-HPV (62.2%) and multiple HR-HPV (16.2%) than HIV-negative women (38.4% and 7.7%, respectively), (P=0.19 and P=0.66, respectively). Most women (84.0%) showed normal cytology, but 16.0% exhibited cervical abnormalities, including 6.0% of Low-grade Squamous Intraepithelial Lesions (LSIL) and Abnormal Squamous Cells with Unknown Significance (ASCUS), and 4.0% of High-grade Squamous Intraepithelial Lesions (HSIL). HPV-16 and HPV-18 were detected in one woman with HSIL. Finally, 87.5% of the study women with cervical abnormalities were HIV-positive, while only one HIV-negative woman showing cervical abnormalities.

Conclusion These findings highlight the unsuspected high burden of cervical HR-HPV infections often associated with cervical abnormalities in the first-generation immigrant women originating from sub-Saharan Africa and residing in France. These observations also point out the atypical epidemiological profile of cervical HPV infection with a rare and non-vaccine high-risk genotype being the most detected HPV, raising thus a concern about the low predictive efficacy of the Gardasil-9® vaccine in the prevention of the main genotypes circulating in these specific population residing in France.

Disclosure No significant relationships.

  • HPV
  • modeling and prevalence
  • vulnerable populations

https://doi.org/10.1136/sextrans-2019-sti.871

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.