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False-negative Chlamydia trachomatis tests uncovered in Finland
Nucleic acid amplification tests are essential for the diagnosis of STIs. A report from Finland recently alerted the STI community about the risk of false-negative Chlamydia trachomatis test results with the Aptima Combo 2 assay. A single-nucleotide mutation in the 23S rRNA gene was likely responsible for the discrepancies. The study provides a warning to laboratories and suggests the need to determine the spread of the mutant clone.1 More broadly, the findings encourage laboratories to keep their molecular methods under regular evaluation and ensure that diagnostic quality is maintained in the face of the natural genetic evolution of bacteria. Euro Surveill May 2019: https://doi.org/10.2807/1560-7917.ES.2019.24.22.1900298
Rapid hepatitis C virus antibody tests delay the diagnosis of recent infection
Routine screening for hepatitis C virus (HCV) infection is recommended for men who have sex with men (MSM) receiving HIV pre-exposure prophylaxis (PrEP).2 In the ANRS IPERGAY PrEP trial, among 429 MSM, HCV incidence was 1.4/100 person-years and was associated with condomless sex, sexualised drug use, fisting …