Introduction The Mpox epidemic placed unprecedented strain on sexual health services: 9% of patients locally required hospitalisation, and the remainder required a daily welfare check by telephone. Remote monitoring systems (RMS) offer effective management of patients within their own homes, affording an opportunity for the management of Mpox.

Methods An existing RMS, in operation in our hospital network, was repurposed to facilitate Mpox management. Mpox training was provided for the RMS nursing team. A bespoke module was developed within Luscii (a GDPR-compliant smartphone app) to support the service. We wished to evaluate the clinical utility of the app in supporting the RMS.

Results 729 patients were referred to the RMS. 221 individuals (30.3%) onboarded with the app, of whom eight later de-registered. The remainder (508/729; 69.7%) elected for daily telephone contact.

Overall, 3646 virtual reviews were performed by telephone and/or the app. At least one trigger was generated by 180/213 app-registered individuals (84.5%). 51/180 (28.3%) required escalation to the on-call sexual health clinician. The remainder were managed by RMS staff by telephone.

Of the 51 individuals requiring intervention, 41/51 (80.4%) attended sexual health services for face-to-face review.

Most escalation alerts (46/51; 90.2%) related to complications of Mpox lesions, of which 38/46 (82.6%) were ano-genital. Other escalations resulted from reports via the app of back pain (1/51; 1.9%), headache (1/51; 1.9%), and low mood (2/51; 3.9%).

Overall, three of the onboarded cohort (3/213 (1.4%) were admitted for inpatient care.

Conclusion The RMS, underpinned by the Luscii app, proved an effective intervention for managing Mpox in an outpatient setting.