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Geographic and demographic clustering of gonorrhoea in London
  1. Claire Risley (c.risley{at}
  1. Imperial College London, United Kingdom
    1. Helen Ward (h.ward{at}
    1. Imperial College London, United Kingdom
      1. Bhudipa Choudhury (b.choudhury{at}
      1. Imperial College London, United Kingdom
        1. Cynthia Bishop (c.bishop{at}
        1. Imperial College, United Kingdom
          1. Kevin Fenton (kif2{at}
          1. National Centers for HIV, STD and TB Prevention, United States
            1. Brian Spratt (b.spratt{at}
            1. Imperial College, United Kingdom
              1. Catherine A Ison (catherine.ison{at}
              1. Health Protection Agency, United Kingdom
                1. Azra Ghani (azra.ghani{at}
                1. LSHTM, United Kingdom


                  Background: Gonorrhoea is an important cause of sexual ill-health and is concentrated in geographic areas and demographic groups. This study explores the distribution of gonorrhoea across London.

                  Methods: Epidemiological data on all gonorrhoea cases were collected from 13 major genitourinary clinics in London between 1st June and 30th November 2004. Samples were stored centrally and typed using NG-MAST. The postcode of each case's main residence was used to calculate incidence of gonorrhoea by borough using data from the UK 2001 census and a population survey on residence of men who have sex with men (MSM).

                  Results: In total 2891 cases were confirmed, 1822 of which had postcode data, resided in London and had their strain successfully typed. There was a very high incidence of gonorrhoea in MSM (1834 per 100,000 population) and heterosexuals of black ethnicity (392 per 100,000). The incidence amongst heterosexuals was highest in: City of London (390 per 100,000, 95% CI 213-566), Southwark (308 per 100,000, 95% CI 280-336), Hackney (284 per 100,000, 95% CI 254-313) and Lambeth (216 per 100,000, 95% CI 194-239) and was not associated with measures of social deprivation (correlation coefficient=0.0008, p=0.97) but was strongly associated with black ethnicity (correlation coefficient=0.48, p=0.01). Forty-five percent of cases had one of the 21 major strains; eight of these strains were significantly clustered geographically and persisted for a shorter duration than those that were not clustered. Patients travelled a mean of 7.7 km from their home to the clinic.

                  Conclusions: High gonorrhoea incidence in London is observed in MSM and heterosexuals of black ethnicity. Endemic strains in both MSM and heterosexuals are diagnosed at multiple clinics. Interventions, including partner notification, must therefore operate between clinics.

                  • epidemiology
                  • ethnicity
                  • geography
                  • gonorrhoea

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