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Miscellanea
Letter
Spontaneous remission of sexually transmitted diseases must be considered in randomised controlled trials
  1. Mary Jane Rotheram-Borus1,
  2. Zunyou Wu2,
  3. Li Li1,
  4. Roger Detels1,
  5. Li-Jung Liang1,
  6. and the NIMH Collaborative HIV/STD Prevention Trial Group
  1. 1University of California at Los Angeles, Semel Institute for Neuroscience and Human Behavior, Center for Community Health, Los Angeles, California, USA
  2. 2National Center for AIDS/STD Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing, China
  1. Correspondence to Dr Mary Jane Rotheram-Borus, University of California, Semel Institute for Neuroscience and Human Behavior, 10920 Wilshire Boulevard, Suite 350, Los Angeles, CA 90024, USA; cchpublications{at}mednet.ucla.edu

https://doi.org/10.1136/sextrans-2011-050009

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    Randomised controlled trials that test biomedical interventions to reduce sexually transmitted infections (STIs) have had very mixed results,1 2 as have behavioural trials.3 4 It is only in the past 10 years that the field has recognised that chlamydia resolves itself without treatment in 50% of the cases,4 although the estimates range from 13% to 60%.5–7 The length of time to clear chlamydia infection varies from 60 days in women to up to 15 months …

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    Footnotes

    • Funding NIMH provided funding for this multisite study.

    • Competing interests None.

    • Patient consent All human subjects signed the informed consent forms that were reviewed and approved by the Institutional Review Boards at UCLA and the China CDC.

    • Ethics approval UCLA SG-IRB; RTI IRB; Chinese Centers for Disease Control IRB.

    • Provenance and peer review Not commissioned; internally peer reviewed.