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Short report
Clinical characteristics of mpox infection in individuals who received a first dose of modified vaccinia Ankara immunisation
  1. Simisola Agunbiade,
  2. Felicity Burton,
  3. Jessica Muirhead,
  4. Gary George Whitlock,
  5. Nicolò Girometti
  1. Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Dr Nicolò Girometti, 56 Dean Street, Chelsea and Westminster Hospital NHS Foundation Trust, London, SW10 9NH, UK; nicogir{at}hotmail.it

Abstract

Introduction A key part of the response to the mpox (monkeypox) epidemic has been the vaccination campaign targeted at gay, bisexual and other men who have sex with men (GBM), including people living with HIV (PLWH).

Methods We undertook a single-site, retrospective analysis of individuals who received a single dose of modified vaccinia Ankara (MVA-BN) prior to the onset of mpox symptoms. Demographics, clinical characteristics and patient management were analysed.

Results Of 10 068 individuals who received a first dose of the MVA-BN vaccination, 15 (0.15%) developed mpox subsequently. All individuals identified were GBM with 12/15 (80%) on Pre-exposure prophylaxis (PrEP) and 3/15 (20%) PLWH. Median time from MVA-BN inoculum to mpox symptoms was 4 days (IQR 3–9), systemic symptoms and supportive medical treatment required were common (11/15 patients, 73%) and all had localising skin lesions. One individual required hospitalisation.

Conclusions Although clinical presentation was similar to unvaccinated cohorts, we observed low numbers of mpox cases following a first dose of MVA-BN vaccination. Larger, multicentric studies are needed to further evaluate vaccination failure and immunity duration.

  • VACCINATION
  • Genital Diseases, Male
  • Communicable Diseases

https://doi.org/10.1136/sextrans-2022-055698

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    Footnotes

    • Handling editor Anna Maria Geretti

    • Contributors NG and GGW contributed to the concept ideation, the writing and the editing of the manuscript. SA, JM and FB contributed to data collection, data analysis and proofreading of the material submitted to the journal.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.