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Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil/emtricitabine is a powerful tool to prevent HIV acquisition and provides an opportunity to offer comprehensive prevention services, including assessment for sexually transmitted infections and evaluation of immune status towards vaccine-preventable viral infections such those due hepatitis A virus (HAV), hepatitis B virus (HBV) and human papillomavirus (HPV). In addition to the programme in girls aged 11–19, French guidelines recommended HPV vaccination for men who have sex with men (MSM) ≤26 years old in February 20161 and for all boys aged 11–19 in December 2019.2 There are no restrictions on HPV vaccine use beyond these age limits, but the cost is not covered by the French Health Service. In real-life settings, suboptimal vaccination coverage against HPV as well as HBV has been reported among European MSM.3 4
Our objective was to evaluate HAV, HBV and HPV vaccine needs and coverage in individuals initiating PrEP in a sexual health clinic in Paris. In this observational retrospective single-centre study, we reviewed all individuals who initiated PrEP between 1 January 2016 and 31 December 2020 with ≥1 year of follow-up after PrEP initiation. At baseline, we assessed the presence of HAV and HBV antibodies and HPV vaccination status. Immune …
Handling editor Anna Maria Geretti
Contributors VB, RP, JD and CK contributed to the study design and developing analysis plan. AFau, JD, RA, CK, VB and AE contributed to the analysis and interpretation of data. VB and AE wrote the first draft of the manuscript and subsequent drafts after revisions. CK reviewed all versions of the manuscript. VB, AE, AFau, JD, LS, AC, AFay, BS, TO, MF, RT, M-AV, VP, ET, GM, RP and CK contributed to the recruitment of participants, reviewed the final version of the manuscript and contributed to the interpretation of the data.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.