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A treatment-naïve 10-year-old female patient living with HIV-1 infection started antiretroviral therapy (ART) in April 2018 with zidovudine+lamivudine+nevirapine, which was changed 19 months later to zidovudine+lamivudine+efavirenz. The HIV-1 RNA load ranged between 55 and 420 copies/mL between February 2020 and May 2021, and was 485 copies/mL in January 2022. At this time, the total HIV-1 DNA load in peripheral blood was 2260 copies/million white blood cells (WBCs) as measured with a HIV-1 DNA quantification kit (Supbio, Guangzhou, China). Genotypic drug resistance testing …
Handling editor Anna Maria Geretti
TW and LZ contributed equally.
Contributors BC directed the clinical treatment, supervised the follow-up and wrote this case report. ML, RZ, TY, AE and SS contributed to the clinical treatment and follow-up. TW and LZ conceived the idea and contributed to the manuscript preparation of this case report.
Funding This work was supported by Chinese Association of STD & AIDS Prevention and Control·Maternal and Child Tigermed Care and Prevention of Maternal to Child Transmission Fund (PMTCT202207), the National Natural Science Foundation of China (81973353), and the Fund of Innovation and Entrepreneurship Leading Team Project of Guangzhou (201809010009).
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.