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Doxycycline postexposure prophylaxis may delay seroconversion in incident syphilis
  1. Angelo Roberto Raccagni1,
  2. Elena Bruzzesi1,
  3. Antonella Castagna1,2,
  4. Silvia Nozza1,2
  1. 1Vita-Salute San Raffaele University, Milan, Italy
  2. 2IRCCS San Raffaele Scientific Institute, Milan, Italy
  1. Correspondence to Dr Angelo Roberto Raccagni, Vita-Salute San Raffaele University, Milan, Italy; raccagni.angelo{at}

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Current serological tests for the diagnosis of syphilis, particularly non-treponemal tests, lack sensitivity in early infection.1 It has been proposed that the delay in treponemal antibody seroconversion may be exacerbated in individuals using doxycycline for postexposure prophylaxis (DoxyPEP).2

We present data on a cohort of men who have sex with men using DoxyPEP who were diagnosed with syphilis infection while taking prophylaxis. …

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  • Handling editor Anna Maria Geretti

  • Contributors ARR and SN visited the individuals and contributed to writing the article. EB visited the individuals contributed to revising the article. AC coordinated clinical activities and contributed to the reviewing of the article. All authors have read and agreed to the published version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer-reviewed.