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Pigmented acuminated condylomas seborrhoeic keratosis-like: a new entity?
  1. Raúl Corbalán-Vélez1,
  2. Jose Antonio Ruiz-Maciá2,
  3. Diego López-Martínez1,
  4. Antonio Moreno Docón3,
  5. Juan Fernández-Pérez2,
  6. Teresa Martínez-Menchón1,
  7. Marta Segado-Sánchez1,
  8. Jose Juan Parra-García1,
  9. Francisco José Martínez-Ortega1,
  10. Julia Román-Gómez1
  1. 1Dermatology Service. Virgen de la Arrixaca University Clinical Hospital, El Palmar, Spain
  2. 2Pathology Anatomy Service, Virgen de la Arrixaca University Clinical Hospital, El Palmar, Spain
  3. 3Microbiology Service, Virgen de la Arrixaca University Clinical Hospital, El Palmar, Spain
  1. Correspondence to Dr Raúl Corbalán-Vélez, Dermatology Service, Virgen de la Arrixaca University Clinical Hospital, El Palmar, Spain; raulcorbalan44{at}


Background Condyloma acuminatum is caused by human papillomavirus (HPV), which typically presents as excrescent, pedunculated, papillomatous lesions which may be of a pale colour. On rare occasions, we have observed pigmented genital lesions that are similar to seborrhoeic keratoses, but with histological findings of condyloma acuminatum and positive genotyping for HPV. We have termed these ‘seborrhoeic keratosis-like’ type condylomas.

Methods This is an observational retrospective study. The following clinical data were collected: age, sex, time of evolution, location, isolated or multiple lesions, monomorphous or polymorphous/mixed lesions. HPV genotyping was performed in all cases, and excision for histological study in eight cases.

Results A total of 31 patients were diagnosed with this type of pigmented condylomata acuminata. Of these, 16 had isolated lesions (less than five lesions) and 15 had multiple lesions. 67% of the lesions exhibited slow growth, with an evolution period of greater than 1 year. The most frequent location was the base of the penis and pubis. HPV genotyping of the lesions was positive in all cases, with the HPV-6 genotype predominating (28 cases, 90.3%). The lesions exhibited dermoscopic differences from other pigmented lesions and histological findings attributable to HPV infection (pseudoparakeratosis, koilocytosis, etc) and others similar to those observed in seborrhoeic keratoses.

Conclusions A total of 31 patients were diagnosed with pigmented verrucous lesions, excrescents, isolated or multiple, in the genital region. These lesions exhibited clinical characteristics similar to seborrhoeic keratoses, with positive genotyping for HPV. In the majority of cases, the genotype was HPV-6. These lesions have been named ‘pigmented condylomata acuminata seborrhoeic keratosis-like’. Only 10 cases of these lesions have been described in the literature.

  • Condylomata Acuminata
  • Human Papillomavirus

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  • Handling editor Miłosz Parczewski

  • Contributors RC-V and JAR-M designed the study after observing several patients with these lesions. RC-V, as lead author, participated in drafting the text and coordinating the different sections of the manuscript. JAR-M and JF-P carried out the histological study of the cases and took the histological photographs. DL-M and TMM selected the numerous photographs for the subsequent preparation of the figures and collaborated greatly in the drafting of the main text and its subsequent modifications. AM-D carried out the HPV serotyping of all cases and contributed to some aspects of HPV. MS-S compiled the data and prepared the table and statistical study. JJP-G, FJM-O and J Román-Gómez collected the samples, recorded the clinical data, performed the dermoscopic examination, took photographs and collected the informed consent forms from different patients. They also carried out a bibliographic review of previous publications on the subject.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.