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Prevalence of co-infection between high-risk human papillomavirus and common sexually transmitted infections in cervical specimens
  1. Joshua Kostera1,
  2. Almedina Tursunovic2,
  3. Paige Botts2,
  4. Regina Galloway2,
  5. April Davis2,
  6. Tong Yang2
  1. 1Abbott Laboratories, Des Plaines, Illinois, USA
  2. 2Ochsner Medical Center, New Orleans, Louisiana, USA
  1. Correspondence to Dr Joshua Kostera, Abbott Laboratories, Des Plaines, Illinois, USA; joshua.kostera{at}abbott.com

https://doi.org/10.1136/sextrans-2024-056137

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    Persistent infection with high-risk human papillomavirus (HPV) is recognised as a primary cause of cervical cancer; however, there is limited information related to the prevalence of co-infection with HPV and other common sexually transmitted pathogens. Emerging evidence suggests that concomitant infection with common sexually transmitted infections (STIs) such as Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG), which target the same mucosal areas of the reproductive tract as HPV, contributes to the development of cervical dysplasia and carcinogenesis in HPV-positive individuals.1 2 Several other synergistic mechanisms influenced by STIs may also favour persistent HPV infection such as alterations in the vaginal microbiome, hormonal changes and disruption of the cervical epithelium that increases viral load and shedding.3 4 Here, we present the prevalence of high-risk HPV with CT, NG, TV and MG co-infection detected using the Alinity m HR HPV assay and Alinity m STI assay (Abbott Molecular, Des Plaines, Illinois, USA) in ThinPrep liquid-based cytology (LBC) cervical specimens from patients undergoing routine cervical cancer …

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    Footnotes

    • Contributors N/A.

    • Funding Consumables and reagents for this study were provided by Abbott Molecular Diagnostics.

    • Competing interests JK is an employee of Molecular Diagnostics for Abbott. Consumables and reagents for this study were provided by Abbott Molecular Diagnostics.

    • Provenance and peer review Not commissioned; internally peer reviewed.