PT  - JOURNAL ARTICLE
AU  - Robbins, J B
TI  - Problems posed by potential gonococcal vaccines viewed from the vantage point of a control agency.
AID  - 10.1136/sti.53.3.170
DP  - 1977 Jun 01
TA  - The British Journal of Venereal Diseases
PG  - 170--172
VI  - 53
IP  - 3
4099  - http://sti.bmj.com/content/53/3/170.short
4100  - http://sti.bmj.com/content/53/3/170.full
SO  - Br J Vener Dis1977 Jun 01; 53
AB  - Progress in the characterisation of Neisseria gonorrhoeae and other bacterial pathogens has suggested that immunoprophylaxis for gonorrhoea may be possible despite the well-known propensity for reinfection. Pili, outer membrane proteins, a capsular polysaccharide, and the lipopolysaccharide may be important gonococcal virulence factors, and immune components (probably antibodies) to more than one of these antigens may be required to confer immunity. A study of antigenic polymorphism of these structures should identify disease isolates more precisely and provide information about the relationship between variants of these gonococcal structures and gonococcal virulence.