RT Journal Article
SR Electronic
T1 Problems posed by potential gonococcal vaccines viewed from the vantage point of a control agency.
JF The British Journal of Venereal Diseases
JO Br J Vener Dis
FD BMJ Publishing Group Ltd
SP 170
OP 172
DO 10.1136/sti.53.3.170
VO 53
IS 3
A1 Robbins, J B
YR 1977
UL http://sti.bmj.com/content/53/3/170.abstract
AB Progress in the characterisation of Neisseria gonorrhoeae and other bacterial pathogens has suggested that immunoprophylaxis for gonorrhoea may be possible despite the well-known propensity for reinfection. Pili, outer membrane proteins, a capsular polysaccharide, and the lipopolysaccharide may be important gonococcal virulence factors, and immune components (probably antibodies) to more than one of these antigens may be required to confer immunity. A study of antigenic polymorphism of these structures should identify disease isolates more precisely and provide information about the relationship between variants of these gonococcal structures and gonococcal virulence.