@article {Notowicz129, author = {A Notowicz and E Stolz and G A de Koning}, title = {First experiences with single-dose treatment of vaginal trichomoniasis with carnidazole (R 25831).}, volume = {53}, number = {2}, pages = {129--131}, year = {1977}, doi = {10.1136/sti.53.2.129}, publisher = {The Medical Society for the Study of Venereal Disease}, abstract = {This paper reports the results of treating 152 women with carnidazole, a new trichomonacidal drug. They were divided into two groups. The first comprised 91 patients who were treated with 2 g, while the second group comprised 61 patients who were treated with 1-5 g carnidazole in a single oral dose. Defaulter rates were 6-6\% for the first group and 13-1\% for the second. Of the remaining 85 patients in the first group, 76 (89-5\%) were negative at the first follow-up one to three weeks after treatment, three (3-5\%) were considered to be treatment failures, and six (7-0\%) were considered to be reinfected. Of 53 women treated with 1-5 g, 39 (73-6\%) were negative at first follow-up, eight (15-1\%) were considered to be treatment failures, and six (11-3\%) were considered to be reinfected. The difference between the number of patients cured in both groups is statistically significant. Fourteen patients experienced side-effects, but these were of little significance. Carnidazole given in a single oral dose of 2 g in 16 women did not cause consistent changes in any of the haematological and biochemical parameters studied.}, issn = {0007-134X}, URL = {https://sti.bmj.com/content/53/2/129}, eprint = {https://sti.bmj.com/content/53/2/129.full.pdf}, journal = {Sexually Transmitted Infections} }