RT Journal Article
SR Electronic
T1 Double-blind comparison of a single dose and a five-day course of metronidazole in the treatment of trichomoniasis.
JF The British Journal of Venereal Diseases
JO Br J Vener Dis
FD BMJ Publishing Group Ltd
SP 354
OP 356
DO 10.1136/sti.55.5.354
VO 55
IS 5
A1 Thin, R N
A1 Symonds, M A
A1 Booker, R
A1 Cook, S
A1 Langlet, F
YR 1979
UL http://sti.bmj.com/content/55/5/354.abstract
AB Although there have been reports of the results of treating trichomoniasis with metronidazole 2 g in a single dose, no randomised double-blind comparison of this treatment with a multiple-dose regimen has been reported. In such a comparison, 96 women were treated with metronidazole 2 g in a single dose and 96 women with metronidazole 400 mg twice daily for five days. Forty-eight of 52 women followed for 14 days after the single dose were cured, as were 61 of 66 women followed for 14 days after the start of the five-day regimen. These results compare favourably with previous reports. Side effects were trivial, and we recommend the single 2-g dose, for it is effective, economical, and can be given under supervision in the clinic.