PT  - JOURNAL ARTICLE
AU  - J D Oriel
AU  - G L Ridgway
TI  - Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis.
AID  - 10.1136/sti.59.4.245
DP  - 1983 Aug 01
TA  - The British Journal of Venereal Diseases
PG  - 245--248
VI  - 59
IP  - 4
4099  - http://sti.bmj.com/content/59/4/245.short
4100  - http://sti.bmj.com/content/59/4/245.full
SO  - Br J Vener Dis1983 Aug 01; 59
AB  - The activity of tetracycline hydrochloride and minocycline hydrochloride was compared against 12 strains of Chlamydia trachomatis and Ureaplasma urealyticum; minocycline was more active in vitro against both organisms. A group of 145 men with non-gonococcal urethritis was treated for one week with either tetracycline hydrochloride 500 mg six hourly or minocycline 50 mg twice daily. The clinical results obtained were similar: 61 of 77 (79%) men treated with tetracycline and 53 of 68 (78%) men treated with minocycline were free from urethritis one to two weeks after completing treatment. Both antibiotics were clinically effective against C trachomatis, but activity against U urealyticum was less consistent. Side effects were noted in 14 (18%) men treated with tetracycline and eight (12%) men treated with minocycline; they were predominantly gastrointestinal.