PT  - JOURNAL ARTICLE
AU  - Warren, C A
AU  - Shannon, K P
AU  - Phillips, I
TI  - In-vitro antigonococcal activity of rosoxacin (WIN 35213).
AID  - 10.1136/sti.57.1.33
DP  - 1981 Feb 01
TA  - The British Journal of Venereal Diseases
PG  - 33--35
VI  - 57
IP  - 1
4099  - http://sti.bmj.com/content/57/1/33.short
4100  - http://sti.bmj.com/content/57/1/33.full
SO  - Br J Vener Dis1981 Feb 01; 57
AB  - The in-vitro activity of rosoxacin against 173 isolates of Neisseria gonorrhoeae, including 17 beta-lactamase-producers, was tested by an agar dilution method. Of the isolates, 167 (including 16 of the beta-lactamase-producers) were inhibited by 0 . 06 mg/l of rosoxacin. The remaining six isolates, one of which produced beta-lactamase and the others were moderately resistant to penicillin, were inhibited by 0 . 12-0 25 mg/l of the compound. There was little correlation between the minimum inhibitory concentrations (MICs) of rosoxacin and penicillin, except for isolates with MICs of penicillin of 0 . 06-1 mg/l, for which correlation was good.