RT Journal Article
SR Electronic
T1 In-vitro antigonococcal activity of rosoxacin (WIN 35213).
JF The British Journal of Venereal Diseases
JO Br J Vener Dis
FD BMJ Publishing Group Ltd
SP 33
OP 35
DO 10.1136/sti.57.1.33
VO 57
IS 1
A1 Warren, C A
A1 Shannon, K P
A1 Phillips, I
YR 1981
UL http://sti.bmj.com/content/57/1/33.abstract
AB The in-vitro activity of rosoxacin against 173 isolates of Neisseria gonorrhoeae, including 17 beta-lactamase-producers, was tested by an agar dilution method. Of the isolates, 167 (including 16 of the beta-lactamase-producers) were inhibited by 0 . 06 mg/l of rosoxacin. The remaining six isolates, one of which produced beta-lactamase and the others were moderately resistant to penicillin, were inhibited by 0 . 12-0 25 mg/l of the compound. There was little correlation between the minimum inhibitory concentrations (MICs) of rosoxacin and penicillin, except for isolates with MICs of penicillin of 0 . 06-1 mg/l, for which correlation was good.