RT Journal Article
SR Electronic
T1 Efficacy of oral treatment with acyclovir and co-trimoxazole in first episode genital herpes.
JF Genitourinary Medicine
JO Genitourin Med
FD BMJ Publishing Group Ltd
SP 33
OP 37
DO 10.1136/sti.62.1.33
VO 62
IS 1
A1 Kinghorn, G R
A1 Abeywickreme, I
A1 Jeavons, M
A1 Rowland, M
A1 Barton, I
A1 Al-Hasani, G
A1 Potter, C W
A1 Hickmott, E
YR 1986
UL http://sti.bmj.com/content/62/1/33.abstract
AB Forty patients presenting with first episode genital herpes were randomly allocated to seven day treatment with oral acyclovir alone, placebo alone, oral acyclovir plus co-trimoxazole, or placebo plus co-trimoxazole. Patients receiving acyclovir had significantly shorter periods of viral shedding (p less than 0.001), pain (p = 0.03), and times to lesion healing (p less than 0.05). Averaged over all patients there was no evidence that co-trimoxazole affected any of the variables, though in women cotrimoxazole was associated with a shorter time to lesion healing (p less than 0.01). Furthermore, the combination treatment gave significantly shorter times to lesion healing than acyclovir alone, placebo alone, or placebo and co-trimoxazole (p = 0.01) and good trends elsewhere (external lesions and duration of pain). Neither drug was associated with any adverse events or toxicity or influenced the subsequent recurrence rate.