RT Journal Article
SR Electronic
T1 Associations between serotype and susceptibility to antibiotics of Neisseria gonorrhoeae.
JF Genitourinary Medicine
JO Genitourin Med
FD BMJ Publishing Group Ltd
SP 86
OP 91
DO 10.1136/sti.65.2.86
VO 65
IS 2
A1 Woodford, N
A1 Bindayna, K M
A1 Easmon, C S
A1 Ison, C A
YR 1989
UL http://sti.bmj.com/content/65/2/86.abstract
AB A serological classification scheme for Neisseria gonorrhoeae was used to investigate the epidemiological associations between gonococcal serotype and other bacterial and host characters. Six hundred and fifty clinical isolates of non-penicillinase producing N gonorrhoeae from the Praed Street Clinic, St Mary's Hospital, were included in this study. The strains collected represented 41 serovars, although 485 (75%) of the 650 strains belonged to five serovars. Strains of serovar IA-1/2 were commonly isolated from the cervix and tended to be sensitive to penicillin and moderately resistant to erythromycin. Strains of serovar IB-1 showed bimodal patterns of susceptibility to both penicillin and erythromycin and were obtained equally from all anatomical sites. Strains of serovar IB-2 were isolated more often from the rectum and were associated with homosexually acquired infections, whereas those of serovar IB-3 were sensitive to erythromycin and were rarely isolated from the rectum. Strains of IB-5/7 were more resistant to penicillin and erythromycin than strains of other serovars. The serological classification of N gonorrhoeae is thus a powerful tool that may be used to study biological characteristics of the gonococcus, such as susceptibility to antimicrobials and site tropism.