RT Journal Article
SR Electronic
T1 Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.
JF Genitourinary Medicine
JO Genitourin Med
FD BMJ Publishing Group Ltd
SP 223
OP 225
DO 10.1136/sti.64.4.223
VO 64
IS 4
A1 van der Valk, P G
A1 Kraai, E J
A1 van Voorst Vader, P C
A1 Haaxma-Reiche, H
A1 Snijder, J A
YR 1988
UL http://sti.bmj.com/content/64/4/223.abstract
AB Penicillin concentrations in cerebrospinal fluid (CSF) were measured in 40 asymptomatic patients with syphilis, 10 of whom had neurosyphilis. The patients were treated with 2.4 MIU procaine penicillin a day intramuscularly in combination with 500 mg probenecid every six hours orally. This intramuscular treatment regimen did not consistently yield treponemicidal penicillin concentrations in the CSF (subtreponemicidal CSF concentrations were found in 17 patients, four of whom had neurosyphilis). These data provide additional evidence that the cure of asymptomatic neurosyphilis is not guaranteed by intramuscular penicillin treatment.