TY - JOUR T1 - Recurrence of condylomata acuminata following cryotherapy is not prevented by systemically administered interferon. JF - Genitourinary Medicine JO - Genitourin Med SP - 91 LP - 93 DO - 10.1136/sti.69.2.91 VL - 69 IS - 2 AU - L J Eron AU - M B Alder AU - J M O'Rourke AU - K Rittweger AU - J DePamphilis AU - D J Pizzuti Y1 - 1993/04/01 UR - http://sti.bmj.com/content/69/2/91.abstract N2 - OBJECTIVE--To determine whether interferon alpha-2a, when utilised as adjuvant chemotherapy following ablation of condylomata acuminata (genital warts) by cryotherapy, is effective in the prevention of recurrences. DESIGN--Randomised, placebo-controlled, double-blind study. Statistical analysis was by 2-tailed Fisher's Exact Test. PATIENTS--97 patients with recurrent condylomata acuminata. INTERVENTION--49 patients were treated with cryotherapy plus subcutaneously administered interferon alpha-2a, and 48 received cryotherapy plus placebo. Of these, 36 and 37 patients, respectively, completed the study and were evaluable. MAIN OUTCOME MEASURE--Clinical eradication of condylomata for six months following adjuvant chemotherapy. RESULTS--By completion of the adjuvant chemotherapy, 10 (28%) interferon recipients and 16 (43%) placebo recipients experienced recurrences. At six months follow-up, 25 (69%) interferon and 27 (73%) placebo recipients experienced recurrences. In the six months following interferon therapy, only 31% of interferon and 27% of placebo recipients remained free of recurrences (p = 0.99). CONCLUSIONS--Interferon alpha-2a administered subcutaneously offers no benefit as a chemotherapeutic adjuvant to cryotherapy when used alone in the therapy of genital warts in this population of patients with recurrent condylomata. ER -