TY - JOUR T1 - Detection of 14-3-3 brain protein in cerebrospinal fluid of HIV infected patients JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 408 LP - 408 DO - 10.1136/sti.76.5.408 VL - 76 IS - 5 AU - R F Miller AU - A J E Green AU - G Giovannoni AU - E J Thompson Y1 - 2000/10/01 UR - http://sti.bmj.com/content/76/5/408.1.abstract N2 - Editor,—The 14-3-3 proteins are a group of highly conserved proteins involved in intracellular signalling. Detection of 14-3-3 brain protein has been described in cerebrospinal fluid (CSF) of patients with transmissible spongiform encephalopathies including both sporadic and variant Creutzfeldt–Jakob disease.1,2 False positive results have been reported in conditions producing (sub)acute neuronal destruction, including herpes simplex encephalitis, ischaemic stroke, multi-infarct dementia, and paraneoplastic syndromes.1–3 We postulated that 14-3-3 brain protein may be detected in CSF from patients with HIV associated dementia complex (HADC) as this condition is characterised neuropathologically by a giant cell … ER -