RT Journal Article
SR Electronic
T1 Combined topical flucytosine and amphotericin B for refractory vaginal <em>Candida glabrata</em> infections
JF Sexually Transmitted Infections
JO Sex Transm Infect
FD BMJ Publishing Group Ltd
SP 212
OP 213
DO 10.1136/sti.77.3.212
VO 77
IS 3
A1 D J White
A1 A R Habib
A1 A Vanthuyne
A1 S Langford
A1 M Symonds
YR 2001
UL http://sti.bmj.com/content/77/3/212.abstract
AB Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clinically and microbiologically.