TY - JOUR T1 - Simvastatin co-prescribed with protease inhibitors despite dangerous drug interactions JF - Sexually Transmitted Infections JO - Sex Transm Infect SP - 498 LP - 499 DO - 10.1136/sti.2007.026070 VL - 83 IS - 6 AU - Katherine M Coyne AU - Marta Boffito AU - Nick Theobald AU - David Asboe Y1 - 2007/10/01 UR - http://sti.bmj.com/content/83/6/498.1.abstract N2 - Drug interactions with anti-retrovirals are frequent and can be dangerous. Protease inhibitors (PIs) inhibit the metabolism of simvastatin, and co-administration is contraindicated. Despite this, we have seen a recent cluster of patients prescribed simvastatin whilst on PIs. A 58-year-old man was taking abacavir, lamivudine, atazanavir and ritonavir. His HIV physician noted raised cholesterol and wrote to the patient and his general practitioner (GP), stating that simvastatin is not recommended with his antiretroviral combination, but low dose atorvastatin or pravastatin … ER -